1
"MOTS-c administration prevented diet-induced obesity and insulin resistance in preclinical models."
View on PubMed →
MOTS-c EU
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MOTS-c is a 16-amino acid mitochondrial-derived peptide encoded within the 12S rRNA gene. It is one of the first peptides discovered to be encoded by mitochondrial DNA rather than nuclear DNA. MOTS-c activates AMPK, a master regulator of cellular energy balance, and has been described in published research as an "exercise mimetic" due to its effects on metabolic pathways involved in glucose uptake, fatty acid oxidation, and insulin sensitivity.
Every batch is independently tested by a 3rd party laboratory. Certificate of Analysis available below.
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Every batch is tested by an independent third-party laboratory with no commercial relationship to Camo Chem. We never self-certify. The full Certificate of Analysis is published on this page and verifiable directly with the testing lab.
Worldwide shipping. UK orders typically delivered in 1-3 working days. EU and international orders 3-7 working days. Tracked and signed-for delivery. Free shipping over £65 (UK) / €110 (EU) / $110 (US).
MOTS-c is highly temperature sensitive. Store lyophilised powder at -20°C. After reconstitution with bacteriostatic water, keep refrigerated at 2-8°C and use within 24 hours. Do not leave at room temperature. Significant degradation occurs within 2-3 hours at ambient temperature.
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3rd Party TestedIndependent lab CoA
≥98% HPLC PurityVerified per batch
Safe DeliveryDiscreet packaging
Research Overview
About this compound
What does the research say?
MOTS-c is unique among peptides because it is encoded by mitochondrial DNA, not nuclear DNA. First characterised in 2015, it activates AMPK through a specific metabolic pathway: it inhibits the folate cycle and de novo purine synthesis, causing accumulation of AICAR, a potent natural AMPK activator.
In preclinical models, MOTS-c administration prevented diet-induced obesity and insulin resistance. Treated subjects showed improved glucose metabolism, enhanced fatty acid oxidation, and reduced fat accumulation compared to controls. Circulating MOTS-c levels have been shown to decline significantly with age in both animal models and human studies, correlating with reduced metabolic efficiency.
These are not marketing claims. These are peer-reviewed, published results. You can verify every reference below.
Why does quality matter with MOTS-c?
MOTS-c is a complex 16-amino acid peptide that requires precise synthesis to maintain its biological activity. Impurities, degradation, or incorrect sequence assembly can render the compound inactive. Many suppliers sell peptides with no third-party verification, relying on self-issued "Certificates of Analysis" that anyone can create in a word processor.
At Camo Chem, every batch is tested by an independent 3rd party laboratory. We publish the full Certificate of Analysis for every batch, and you can verify the results directly with the lab. We do not self-certify. Ever.
Ask your current supplier: who tests their products?
Technical Data
Compound specifications
| Common Names | MOTS-c, MOTSc, Mitochondrial Open Reading Frame of the 12S rRNA-c |
| CAS Number | 1627580-64-6 |
| Sequence | MRWQEMGYIFYPRKLR (Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg) |
| Molecular Formula | C₁₀₁H₁₅₂N₂₈O₂₂S₂ |
| Molecular Weight | 2,174.64 g/mol |
| Amino Acids | 16 |
| Classification | Mitochondrial-derived peptide (MDP) |
| Purity | ≥98% (HPLC verified) |
| Content per Vial | 10 mg |
| Physical Form | Lyophilised (freeze-dried) white powder |
| Solubility | Soluble in water and bacteriostatic water |
| Storage | Lyophilised: store at -20°C. After reconstitution: 2-8°C, use within 24 hours. MOTS-c degrades rapidly at room temperature. |
Peer-reviewed Studies
Published research on MOTS-c
2
"MOTS-c activates AMPK and reproduces key metabolic adaptations associated with exercise training in preclinical studies."
View on PubMed →3
"Circulating MOTS-c levels decline significantly with age, correlating with reduced metabolic efficiency and insulin sensitivity."
View on PubMed →
Customer Reviews
What researchers are saying
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FAQ
Frequently asked questions
MOTS-c is a 16-amino acid peptide encoded by mitochondrial DNA, specifically within the 12S rRNA gene. Its CAS number is 1627580-64-6. It is classified as a mitochondrial-derived peptide (MDP) and is one of the first peptides discovered to be encoded by mitochondrial rather than nuclear DNA. It is sold exclusively as a research compound.
Most peptides are encoded by nuclear DNA. MOTS-c is encoded by mitochondrial DNA, making it part of a small and recently discovered class called mitochondrial-derived peptides (MDPs). It acts primarily through AMPK activation, a pathway more commonly associated with exercise and metabolic regulation than with traditional peptide signalling.
Every batch meets a minimum of 98% purity as verified by HPLC. Testing is performed by an independent 3rd party laboratory. The Certificate of Analysis for the current batch is available on this page and can be verified directly with the lab.
By an independent laboratory with no commercial relationship with our company. We do not self-certify. Many competitors issue their own "Certificates of Analysis," which provides no real quality guarantee. Our CoAs are verifiable directly with the testing lab.
MOTS-c is highly temperature sensitive. Store the lyophilised powder at -20°C. After reconstitution with bacteriostatic water, refrigerate at 2-8°C and use within 24 hours. Do not leave at room temperature; published data indicates significant degradation within 2-3 hours at ambient temperature.
Yes. MOTS-c is supplied as a lyophilised powder and must be reconstituted with bacteriostatic water before use. We sell bacteriostatic water separately.
